Vitamin K2 MK-7 Natto 100mcg 120 Capsules
VITAMIN K2 - WHAT IS IT?
Vitamin K2 MK7 is a subtype of Vitamin K, also known as Menaquinone, or simply MK7. Vitamin K2 Formulation has been specially developed to provide the body with adequate amounts of Vitamin K2 to meet its daily needs. Vitamin K2 functions in the body are linked to blood clotting, bone protein synthesis and vascular protection.
Booster Vitamin K2 MK7 supplements is formulated from an imported natural source, whose raw material is certified. Among the scholars of the subject it is known that the best natural food source of Vitamin K2 is natto. Natto is a traditional Japanese food, 100% natural made from soy beans fermented by bacillus subtilis. Its final product is a probiotic, proteinic and vitamin K2-rich food of the MK7 type. However, natto is not a popular product in the Western world, and vitamin K2 supplementation derived from this source may be a good alternative.
DIFFERENCE BETWEEN VITAMIN K1, VITAMIN K2 MK4,
VITAMIN K2 MK7 AND VITAMIN K3
Vitamin K1 (Filoquinone) is derived from foods of plant origin, Vitamin K2 or Menaquinones (MK) is of bacterial origin, being produced by bacteria in the colon and can be found in fermented foods, especially cheese and Natto (soy) while Vitamin K3 (Menadione) is a synthetic compound.
There are several different forms of Vitamin K2, with MK-4 and MK-7 being the most used forms in nutritional supplements.
Among these types of vitamins K, the type Vitamin K2 MK-7 when consumed, is almost totally absorbed. Vitamin K2 MK-4 in supplements is of synthetic origin and does not remain at therapeutic levels in the blood for a long time, therefore its bioavailability is lower. While the Vitamin K2 MK-7 is of natural origin it is extracted from Natto. Natto is considered the largest and best source of Vitamin K2 type MK-7. Another major advantage of MK-7 over MK-4 is that it remains in the blood at therapeutic doses for much longer, about three days.
Vitamin K2 is a lipid soluble vitamin that plays essential roles in the biosynthesis of various proteins involved in blood clotting, bone mineralization and vascular health.
Being a food supplement and mainly formulated from a natural source, Vitamin K2, does not cause adverse effects. The Vitamin K2 supplement aims to combat the nutritional deficiency of Vitamin K2, thus preventing the manifestation of metabolic disorders that vitamin K2 deficiency can promote.
Vitamin K2 action of in the body can be reflected in several areas and organs and especially in the functions of blood coagulation, bone maintenance and vascular health.
Vitamin K2 MK7 Benefits
Although not very popular, in recent years, there has been growing scientific evidence of the benefits of Vitamin K2, proving more essential in maintaining health.
Understand the functions and specific areas of action of Vitamin K2 in the body:
Vitamin K generally acts as an essential cofactor in the blood coagulation reaction. It mediates the formation of specific residues of glutamic acid, which leads to the ability of the coagulation proteins to bind to calcium, thus allowing interaction with the phospholipids of the platelet and endothelial cells membranes, which in turn enables the process of normal blood coagulation. In addition to playing a key role in blood coagulation, it is now known that Vitamin K2 plays an important role in bone formation and regulation of multiple enzyme systems.
Vitamin K2 is an essential micronutrient for bone health. Osteocalcin, a bone-specific protein produced by osteoblasts, requires the presence of Vitamin K2 to be matured and thus to perform its functions on bone mineralization. The presence of Vitamin K2 ensures the activation of bone proteins that regulate bone remodeling, a process necessary to maintain bone health.
Therefore, adequate intake of Vitamin K2 may be beneficial for bone health, fracture reduction, and calcium homeostasis.
Vitamin K2 appears to be related to blockage of calcium deposition that is caused by an inflammatory reaction. Generally if this occurs in the blood vessels is a sign that there is plaque formation in the artery (atherosclerosis), this can be a problem that will be reflected on the health of the heart.
Vitamin K2 involvement in artery protection is explained by its role in the activation of matrix GLA (MGP). MGP binds to Calcium and inhibits the calcification of soft and cardiovascular tissues, playing a protective role for the blood vessels.
How Vitamin K works?
Vitamin K was discovered in 1929 as an anti-hemorrhagic factor, capable of restoring blood disorders. Several investigations culminated in the discovery of coagulation factors (prothrombin, factors VII, IX, and X) that contained an amino acid, gamma carboxyglutamic acid (Gla). Vitamin K acts as an essential cofactor in the carboxylation reaction of specific residues of glutamic acid (Glu), leading to the formation of Gla. Carboxylation enables coagulation proteins to bind to calcium, thereby allowing interaction with the phospholipids of platelet membranes and endothelial cells, which, in turn, enables the normal blood coagulation process.
Therefore, Vitamin K2 is considered a cofactor of numerous biochemical pathways, since it participates in the activation and acceleration of several processes.
The most common biochemical reaction of Vitamin K2 is the carboxylation reaction, which maintains its proposed mechanism of action.
In bone structure, osteocalcin is a protein secreted by osteoblasts, and is directly involved in the regulation of bone maturation. Vitamin K2 is responsible for maintaining the proper functioning of this protein through the activation of the carboxylation process. Osteocalcin when passing through the carboxylation has the ability to fix the circulating calcium in the bone, thus promoting bone mineralization. If osteocalcin does not undergo the carboxylation process exerted by Vitamin K2, it is inactivated and cannot keep calcium bound to the bone, which can make them weak, increasing the risk of fractures and associated diseases. In this way, the activation of osteocalcin by Vitamin K2 serves as a serum bone marker to predict the risk of fractures.
Many elderly people, perhaps 50% of them, have inadequate intake of vitamin K2, especially when the consumption of dark green vegetables is low.
In addition to participating in the fixation of calcium in the bone, Vitamin K2 participates in the carboxylation of the Gla protein (MGP). This protein exerts a function under the inhibition of calcification of the arteries. In its full functioning, after being carboxylated by Vitamin K2, the Gla protein of the Matrix (MGP) prevents the deposition of arterial calcium, that is, removes calcium from the arteries preventing the formation of plaques and cardiovascular risks.
Therefore, when vitamin K2 is deficient, the matrix Gla protein (MGP) is impaired because it has not undergone the carboxylation process. This impairs the normal function of the process of removing calcium from the arteries, increasing the risk of arterial calcification. Therefore, Vitamin K2 promotes the normal functioning of the matrix Gla protein (MGP), which can prevent calcium from depositing in the arteries, contributing to the maintenance of cardiovascular health.
The advantage of supplementing Vitamin K in its Vitamin K2 MK7 form is that it will already be offered to the body in its active form and can be absorbed and sent to the target organs without having to undergo bacterial action.
Vitamin K2 supplementation in people with warfarin or other anticoagulants is not recommended as it may inhibit the effect of these drugs.